Association between insulin resistance and inflammatory cytokines among obese Saudi type 2 diabetic with vitamin D deficiency
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Fadwa M. Al-Sharif 1
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1 King Abdulaziz University, Saudi Arabia

Abstract

Introduction:
Vitamin D deficiency is now considered a public health problem around the world that is strongly associated with all-cause and cardiovascular mortality. However, vitamin D deficiency may play a role in mediating low-grade inflammation and insulin resistance among type 2 diabetic patients.

Material and Methods:
One hundred obese Saudi patients with T2DM (60 males and 40 females). Their age was46.38 ± 7.53 year, and a control group included one hundred healthy volunteers, who was gender and age matched.

Results:
Obese T2DM patients showed significantly higher glucose, insulin, glycosylated hemoglobin (HBA1c), Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) index, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and C-reactive protein(CRP) in addition to significantly lower values of the quantitative insulin-sensitivity check index (QUICKI) and 25(OH) vitamin D levels in comparison to controls. Serum levels of TNF-α , IL-6 and CRP showed an inverse relationship with QUICKI and a direct relationship with HOM-IR and HBA1c among obese Saudi type 2 diabetic with vitamin D deficiency.

Conclusions:
Within the limit of there is an association between insulin resistance and inflammatory cytokines among obese Saudi type 2 diabetic with vitamin D deficiency.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

https://doi.org/10.29333/ejgm/81757

EUR J GEN MED, 2016 - Volume 13 Issue 4, pp. 91-96

Publication date: 03 Dec 2016

Article Views: 830

Article Downloads: 730

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