Antithyroid Antibody Levels in Patients with Breast Cancer
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Haluk Dülger 1 * , Süleyman Alıcı 2, Ekrem Algün 3, Ömer Etlik 4, Mehmet Sayarlıoğlu 5, Ekrem Doğan 5, Hayriye Sayarlıoğlu 5, M. Ramazan Şekeroğlu 1
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1 Yüzüncü Yıl University, Faculty of Medicine, Department of Biochemistry, Van, Turkey
2 Yüzüncü Yıl University, Faculty of Medicine, Department of Medical Oncology, Van, Turkey
3 Yüzüncü Yıl University, Faculty of Medicine, Department of Endocrinology, Van, Turkey
4 Yüzüncü Yıl University, Faculty of Medicine, Department of Radiology, Van, Turkey
5 Yüzüncü Yıl University, Faculty of Medicine, Department of Internal Medicine, Van, Turkey
* Corresponding Author

Abstract

Breast cancer is a hormone-dependent neoplasm. Conflicting results regarding the clinical correlation between breast cancer and thyroid diseases have been reported. The aim of this study was to determine the goiter prevalence, thyroid hormones and antithyroid antibody levels in patients with breast cancer. For this purpose, thyroid ultrasonography was performed and serum levels of free triiodothyronine (FT3 ), free thyroxine (FT4 ), thyroid-stimulating hormone (TSH), anti-thyroid peroxidase antibodies (anti-TPO ab) and anti-thyroglobulin antibodies (anti-TG ab) were determined in 50 operable breast cancer patients at the time of diagnosis and 30 healthy individuals as control group. Goiter prevalence was found to be significantly higher in the study group (50% vs 10%). FT3 , FT4 , and TSH levels of patients were not different compared to controls, whereas anti-TPO ab and anti-TG ab levels were significantly higher in patients than in the control group. In conclusion, goiter prevalence and thyroid antibody levels were found to be increased in breast cancer patients and thyroid functions should be monitored.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

https://doi.org/10.29333/ejgm/82174

EUR J GEN MED, 2004 - Volume 1 Issue 2, pp. 11-14

Publication date: 15 Apr 2004

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