An extremely rare case with diagnoses of cerebral amyloid angiopathy, idiopathic normal pressure hydrocephalus, and dementia with Lewy bodies
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Suleyman Emre Kocyigit 1 * , Kerime Basaran 2 , Derya Kaya 3 , Hasan Bozkurt 4 , Erdogan Bulbul 5 , Ahmet Turan Isik 3
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1 Department of Geriatrics, Balikesir University, Balikesir, TURKEY2 Department of Internal Medicine, Balikesir University, Balikesir, TURKEY3 Department of Geriatric Medicine, Dokuz Eylul University, Izmir, TURKEY4 Division of Nuclear Medicine, Ataturk City Hospital, Balikesir, TURKEY5 Department of Radiology, Balikesir University, Balikesir, TURKEY* Corresponding Author

Abstract

Introduction: Inflammatory cerebral amyloid angiopathy (iCAA) is an inflammatory condition seen in cerebral amyloid angiopathy (CAA) which is a disease pathologically characterized by β-amyloid deposition in the walls of cortical and leptomeningeal arteries. It contributes independently to cognitive impairment in older adults and is most commonly associated with Alzheimer’s disease (AD).
Case reports: We describe a 73 year old male patient presenting with rapidly progressive cognitive decline with clinical dementia syndromes other than AD, namely idiopathic normal pressure hydrocephalus and dementia with Lewy bodies at the same time, who is not widely thought to be related to CAA and thus may have been overlooked.
Conclusion: This case is striking to illustrate that inflmmatory CAA may also present in the context of multiple neurodegenerative diseases and interact with them leading to be an independent variable for rapidly progressive decline and immunosupressive treatment may help slow down the cognitive decline and cause improvement in Daily living activities in the life of older adults. It is of importance to diagnose and manage iCAA for the accurate patient care and for research settings.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Case Report

ELECTRON J GEN MED, Volume 23, Issue 4, August 2026, Article No: em748

https://doi.org/10.29333/ejgm/19178

Publication date: 19 Aug 2026

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