Fibrolamellar carcinoma of the liver is a variant of hepatocellular carcinoma.
It is relatively common in young people and has equal gender
distribution. The disease presents as abdominal pain, weight loss and
malaise. In several reports of fibrolamellar liver tumors, high cobalamin
level has been demonstrated in the human’s serum. Therefore,
serum cobalamin has been found as a good tumour marker for fibrolamellar
hepatocellular carcinoma. Elevated production or decreased
elimination of haptocorrin may play an important role for this phenomen.
For early fibrolamellar carcinoma, surgical resection, when
feasible, is the gold standart for the treatment. In advanced stage of
the disease; single-modality treatments (recombinant interferon α-2b
or sorafenib) can be tried. Herein, we report a case of metastatic
fibrolamellar hepatocellular carcinoma that was presented with high
vitamin B12 levels and continued subcutaneous recombinant interferon