A Case of Fibrolamellar Hepatocellular Carcinoma Presented with Elevated Serum Vitamın B12 Levels
Ahmet Cumhur Dülger 1 * , Murat Atmaca 1, Enver Aytemiz 1, Ebru Altındal 1, Hüseyin Akdeniz 1
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1 Yuzuncuyil University School of Medicine, Van, Turkey
* Corresponding Author


Fibrolamellar carcinoma of the liver is a variant of hepatocellular carcinoma. It is relatively common in young people and has equal gender distribution. The disease presents as abdominal pain, weight loss and malaise. In several reports of fibrolamellar liver tumors, high cobalamin level has been demonstrated in the human’s serum. Therefore, serum cobalamin has been found as a good tumour marker for fibrolamellar hepatocellular carcinoma. Elevated production or decreased elimination of haptocorrin may play an important role for this phenomen. For early fibrolamellar carcinoma, surgical resection, when feasible, is the gold standart for the treatment. In advanced stage of the disease; single-modality treatments (recombinant interferon α-2b or sorafenib) can be tried. Herein, we report a case of metastatic fibrolamellar hepatocellular carcinoma that was presented with high vitamin B12 levels and continued subcutaneous recombinant interferon α-2b thrice-weekly.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Case Report


EUR J GEN MED, 2011 - Volume 8 Issue 3, pp. 250-252

Publication date: 11 Jul 2011

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