Mechanism of Action of Jatropha Gossypifolia Stem Latex As a Haemostatic Agent
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Taofeeq Oduola 1 * , Ganiyu Oyebola Adeosun 2, Tesleem Aderemi Oduola 3, Godwin Ovie Avwioro 4, Mutiyat Adeyoola Oyeniyi 1
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1 Obafemi Awolowo University Teaching Hospital Complex, School of Medical Laboratory Sciences, Department of Hematology, Ile-Ife, Osun State, Nigeria.2 Obafemi Awolowo University Teaching Hospital Complex, School of Medical Laboratory Sciences, Department of Chemical Pathology, Ile-Ife, Osun State, Nigeria.3 Obafemi Awolowo University Teaching Hospital Complex, School of Medical Laboratory Sciences, Department of Medicine, Ile-Ife, Osun State, Nigeria.4 Obafemi Awolowo University Teaching Hospital Complex, School of Medical Laboratory Sciences, Department of Histopathology, Ile-Ife, Osun State, Nigeria.* Corresponding Author

Abstract

Aim: Jatropha gossypifolia belongs to the family “Euphorbiacea”. The coagulant activity and the mechanism of action of Jatropha gossypifolia stem latex as a haemostatic agent were investigated. Methods: The mechanism of action was investigated using doubling dilution technique by mixing neat (undiluted) and serial dilutions of the latex with 30% bovine albumin. Results: The results of whole blood clotting time using Lee and White method and bleeding time using Ivy’s method were significantly reduced (P < 0.05) when stem latex was introduced than when the tests were performed without stem latex. This means that the stem latex possesses procoagulant activity. Conclusion: The result of this test showed that precipitation of coagulant factors is the mechanism of action of its haemostatic activity.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

EUR J GEN MED, 2005, Volume 2, Issue 4, 140-143

https://doi.org/10.29333/ejgm/82329

Publication date: 15 Oct 2005

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