Mean Platelet Volume may be Reflects the Disease Activity of Ulcerative Colitis
Mustafa Güçlü 1 * , Hakan Sakallı 1, Tolga Yakar 1
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1 Başkent University, Faculty of Medicine, Adana, Turkey* Corresponding Author

Abstract

Aim: To determine the relation between the disease activity of ulcerative colitis and mean platelet volume (MPV) and to evaluate the clinical usage of a more simple and easier determinant. Method: Complete blood count, C-reactive protein (CRP), erythrocyte sedimentation ratio (ESR), serum albumine and prothrombine time were measured in a total of 41 ulcerative colitis patients. The clinic, pathologic, colonoscopic disease activities of ulcerative colitis and the localisation of colonic involvement were designated. Truloeve-Witts score was used for the clinic activity of ulcerative colitis. Result: Eleven patients were in remission (26.8%) and 30 had active disease (73.2%). The mean values were; age: 44.58±15.08 year (20 women, 21 men), CRP: 36.80±32.90 mg/L, ESR: 52.29±31.23 mm/h, albumin: 3.43±0.65 gr/dl, platelets: 400780±161196 K/mm3, MPV: 7.41±1.04 fentoliter (fl), prothrombine time: 13.32±1.05 second, respectively. By the correlation analysis there was a negative significant relation between CRP and MPV (p<0.05). The mean MPV values of the 11 patient in remission were 8.62±1.15 fl. The mean MPV values of the 30 patients who had active disease were 6.97±0.53 fl. The patients having active ulcerative colitis had lower MPV values when compared with the patients who had inactive disease (in remission) (p<0.001). There were negative significant relations between MPV and clinical, pathological aand colonoscopic activity indices (p<0.001). However there was no relation between the extent of the disease involvement and MPV. Conclusion: MPV can reflect the disease activity of ulcerative colitis.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

EUR J GEN MED, 2010, Volume 7, Issue 3, 259-263

https://doi.org/10.29333/ejgm/82865

Publication date: 12 Jul 2010

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