CD4, CD8 and MHC Class I Expression in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma: An Immunohistochemical Study
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Dyah R. Budiani 1, Sofia M. Haryana 2, Marsetyawan HNE Soesatyo 2, Wihaskoro Sosroseno 3 *
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1 Sebelas Maret University, Faculty of Medicine, Department of Pathology, Surakarta, Indonesia2 Gadjah Mada University, Faculty of Medicine, Department of Histology and Cell Biology, Yogyakarta, Indonesia3 AIMST University, Faculty of Dentistry, Semeling, Bedong, Kedah Darul Aman, Malaysia* Corresponding Author

Abstract

Aim: The exact immunopathogenesis of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) remains unclear. The aim of the present study was to assess the expression of CD4, CD8, and MHC class I molecules in NPC. Method: Biopsies were obtained from patients with NPC as well as the Epstein Barr virus (EBV)-seronegative patients as a control. Nasopharyngeal carcinoma patients were classified using the World Health Organization (WHO) pathological assessment and clinical staging of NPC. The expression of CD4, CD8, and MHC class I in the biopsies were assessed immunohistochemically. Result: The results showed that the number of CD4 positive, CD8 positive, and MHC class I positive cells in NPC patients were higher than those in EBV-negative subjects (p<0.05). The number of these positive cells in NPC patients with WHO Type II or early clinical stage was not significantly differences with those with WHO Type III or late clinical stage, respectively (p>0.05). No statistical differences between the number of CD4 positive and CD8 positive cells in NPC patients could be found (p>0.05). Conclusion: The results of the present study suggest, therefore, that the expression of CD4, CD8 and MHC class I molecules may not be associated with the pathologic classification and clinical staging of NPC and that the CD4:CD8 ratio in nasopharyngeal carcinoma may indicate decreased functions of these infiltrating T cell subsets.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

EUR J GEN MED, 2010, Volume 7, Issue 3, 277-281

https://doi.org/10.29333/ejgm/82868

Publication date: 12 Jul 2010

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