ORIGINAL ARTICLE
The effect of telithromycin on inflammatory markers in chronic obstructive pulmonary diseases
Taha Bekçi 1  
,  
Recep Kesli 2
,  
Emin Maden 3
,  
 
 
More details
Hide details
1
Konya Training and Research Hospital, Pulmonology Department, Konya, Turkey
2
Konya Training and Research Hospital, Microbiology Department, Konya, Turkey
3
Selçuk University, Meram Medical Faculty, Department of Pulmonary Medicine, Konya, Turkey
Online publish date: 2009-10-15
Publish date: 2009-10-15
 
Eur J Gen Med 2009;6(4):218–222
KEYWORDS:
ABSTRACT:
Aim: To evaluate the anti-inflammatory effect of telithromycin on sputum interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) levels in patient with chronic obstructive pulmonary diseases (COPD). Methods: Thirty four patients with mild to moderate COPD were enrolled in this prospective, single center, double-blind, placebo controlled study. Subjects received either telithromycin or placebo for 10 days. Before and after treatment period spirometric tests, arterial blood gas analyses were performed, sputum samples were taken for measurement of sputum inflammatory markers, and sputum was induced. Results: There was no statistical difference in baseline clinical or laboratory parameters between groups. After the treatment, the induced sputum IL-8, TNF-α, MPO levels is similar compared with pretreatment levels. Conclusion: In this study, anti-inflammatory effects of telithromycin in stable COPD patients were not demonstrated. Further studies are needed to determine the clinical significance of these findings.
CORRESPONDING AUTHOR:
Taha Bekçi   
Konya Eğitim Araştırma Hastanesi Göğüs Hastalıkları Servisi Konya
eISSN:2516-3507