The Link Between Cardio-Metabolic Risk Factors, Serum sIL-2R and Echocardiography Data in Type 2 Diabetes
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College of Medicine Al-Mustansiriya University Baghdad, Iraq
The laboratories of Al-Yarmouk Teaching hospital Ministry of Health Baghdad, Iraq
The laboratories of Al-Yarmouk Teaching Hospital Baghdad, Iraq
Publish date: 2015-04-15
Eur J Gen Med 2015;12(2):104–108
This study aimed to demonstrate the link between the inflammatory process, cardio-metabolic risk factors and echocardiography data in type 2 diabetic (T2D) patients. A total number of fifty-two patients (12 male and 40 females) with a median age of 57 year were enrolled in this study. Anthropometric measurements that related to the cardio-metabolic risk factors and blood pressure were measured. Fasting serum glucose, lipid profiles and soluble interleukin -2 receptor (sIL-2R) using the technique of enzyme linked immunnosorbent assay (ELISA) were determined. The patients categorized according to the presence of metabolic syndrome components using the National Cholesterol Education program (NCEP) definition. Echocardiography data that related to systolic and diastolic left ventricular dysfunction were recorded using B-mode ultrasound with a frequency of 2-4MHz. There was non-significant difference in echocardiography data that related to systolic and/or diastolic dysfunction and the cardio-metabolic risk factors. The mean serum sIL-2R level was 3.469±3.062 pg/ml (range: 1.316-12.5); it inversely and non-significantly correlated with ejection fraction (r = - 0.12) and atherogenic index (r=-0.148). There is a link between the left ventricular systolic function and the circulating sIL-2R in asymptomatic T2D, which does not relate to the components of metabolic syndrome.
Marwan SM Al-Nimer   
Department of Pharmacology College of Medicine, Al-Mustansiriya University