ORIGINAL ARTICLE
THE CHANGES OF ZINC, COPPER, AND IRON LEVELS IN LUNG TISSUE AFTER FORMALDEHYDE INHALATION DURING THE EARLY POSTNATAL PERIOD OF RATS
 
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1
Afyon Kocapete University, Faculty of Medicine, Department of Anatomy, Afyon, Turkey
2
Fırat University, Faculty of Medicine, Department of Anatomy, Elazığ, Turkey
3
Gaziosmanpaşa University, Faculty of Medicine, Department of Biochemistry, Tokat, Turkey
4
Mustafa Kemal University, Faculty of Medicine, Department of Biochemistry, Hatay, Turkey
5
Firat University, Faculty of Science and Arts, Department of Chemistry, Elazığ, Turkey
CORRESPONDING AUTHOR
Ahmet Songur   

Afyon Kocatepe Üniversitesi, Tıp Fakültesi Anatomi A.D. Afyon, TURKEY Phone: 902722140152, Fax: 902722142060
Online publish date: 2005-04-15
Publish date: 2005-04-15
 
Eur J Gen Med 2005;2(2):62–68
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ABSTRACT
Aim: In this study, effects of inhaled formaldehyde (FA) gas, during early postnatal period on the levels of zinc, copper and iron elements and activity of total superoxide dismutase (t-SOD) enzyme in lung tissue and also the reversibility of effects of formaldehyde were examined. Methods: For this purpose newly born albino Wistar rats were exposed to 0 (control), 6 or 12 ppm FA gas for 30 days. After the treatment, rats were decapitated in 30th and 90th days. Activities of t-SOD and the levels of zinc, copper and iron were measured in lung samples. Results: A decrease in the t-SOD activity, copper and iron levels and increase in zinc levels were found in the treatment groups in comparison with control group at both 30th and 90th days measurements. Conclusion: It was thought that exposure to FA may alter the trace element levels of lung tissue including copper, zinc and iron, and induce further oxidative damage on lung tissue.
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