ORIGINAL ARTICLE
Rickets, vitamin D deficiency, adolescents
Celal Yavuz 1  
,  
Ömer Çakır 1
,  
Mustafa Göz 1
,  
Ebru Kale 1
,  
 
 
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1
Dicle University, Medical School, Diyarbakır, Turkey
CORRESPONDING AUTHOR
Celal Yavuz   

GATA Haydarpaşa Hastanesi, Kalp Damar Cerrahisi Kliniği, İstanbul, Turkey
Publish date: 2010-01-12
 
Eur J Gen Med 2010;7(1):76–80
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ABSTRACT
Aim: The aim of this study was to investigate the effects of sodium nitroprussid (SNP) on ischemia-reperfusion injury in rats. Method: Twenty-four Sprague-Dawney rats were divided into four equal groups: group I without ischemia-reperfusion (I-R); group II with ischemia; group III with I-R; group IV with I-R and SNP. Complete bilateral hindlimb ischemia was produced by means of tourniquet occlusion of the upper thigh. Result: Blood creatine phosphokinase, lactate dehydrogenase, aspartate transaminase, urea, creatinine levels were not significantly different between groups 3 and 4. Malondialdehyde (MDA) levels were not significantly different between groups 3 and 4 in liver, soleus muscles and lung tissue. However, MDA levels were significantly lower in group 4 when compared with group 3 in renal tissue. Histological examination of the soleus muscles revealed that neutrophil leukocyte infiltration in group 3 was significantly less prominent than in group 4. Conclusion: These results have shown that SNP was not able to improve muscle ischemia-reperfusion injury in our study.
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