REVIEW ARTICLE
Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome and Malignancy
 
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Yüzüncü Yıl University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Van, Turkey
CORRESPONDING AUTHOR
Mehmet Sayarlıoğlu   

Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Araştırma Hastanesi, İç Hastalıkları AD, Romatoloji BD. 65200 Van, Turkey Telephone:+90 532 2239020 Fax:+90 432 2155051
Online publish date: 2004-04-15
Publish date: 2004-04-15
 
Eur J Gen Med 2004;1(2):3–5
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ABSTRACT
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a definite subset of the seronegative symmetrical polyarthritis of the aged, characterized by dramatic pitting edema of the hands, male predominance, old age and exquisite response to corticosteroids. RS3PE syndrome is a rare but well-defined syndrome known to be associated with solid tumors and haematologic malignancies. Recent research has shown that it is not a specific entity but rather a syndrome that can represent the inaugural form of various types of rheumatic disease and neoplastic conditions of the elderly. A thorough examination in elderly patients with RS3PE syndrome, and heightened suspicion of potential underlying malignant disease is necessary.
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