ORIGINAL ARTICLE
PROTECTIVE EFFECTS OF QUERCETIN, A FLAVONOID ANTIOXIDANT, IN ABSOLUTE ETHANOL-INDUCED ACUT GASTRIC ULCER
 
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1
Karaelmas University, Faculty of Medicine, Department of Medical Histology-Embryology, Zonguldak, Turkey
2
Karaelmas University, Faculty of Medicine, Department of Biochemistry, Zonguldak, Turkey
Online publish date: 2004-07-15
Publish date: 2004-07-15
 
Eur J Gen Med 2004;1(3):37–42
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ABSTRACT:
Free radicals have been reported to be responsible for many ailments including gastroduodenal ulcers. Recent studies demonstrated that quercetin (QE) has an antioxidant effects on injuries caused by various toxic agents in different experimental models. In our study, we examined anti-ulcerogen and antioxidant effects of quercetin on ethanol-induced gastric lesions in rats. QE was administered intraperitoneally (i.p.) 50 mg/kg. It was found that pretreatment with QE significantly reduced ethanol-induced gastric damage and malondialdehyde levels, and significantly increased antioxidant enzyme activities. We conclude that QE clearly has antioxidant properties and that the protective effect of QE against ethanol-induced gastric mucosal lesion, at least in part, depends upon the reduction in the lipid peroxidation and an increase in the activity of antioxidant enzymes.
CORRESPONDING AUTHOR:
Ömer Coşkun   
Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi Histoloji-Embriyoloji AD Zonguldak- Turkey Tel: +903722577394 Fax: +903722577395
eISSN:2516-3507