ORIGINAL ARTICLE
Mechanism of Action of Jatropha Gossypifolia Stem Latex As a Haemostatic Agent
 
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1
Obafemi Awolowo University Teaching Hospital Complex, School of Medical Laboratory Sciences, Department of Hematology, Ile-Ife, Osun State, Nigeria.
2
Obafemi Awolowo University Teaching Hospital Complex, School of Medical Laboratory Sciences, Department of Chemical Pathology, Ile-Ife, Osun State, Nigeria.
3
Obafemi Awolowo University Teaching Hospital Complex, School of Medical Laboratory Sciences, Department of Medicine, Ile-Ife, Osun State, Nigeria.
4
Obafemi Awolowo University Teaching Hospital Complex, School of Medical Laboratory Sciences, Department of Histopathology, Ile-Ife, Osun State, Nigeria.
CORRESPONDING AUTHOR
Taofeeq Oduola   

Obafemi Awolowo University Teaching Hospital Complex, Departments of Hematology, Ile-Ife, Osun State, Nigeria. Phone: 2348033968785
Online publish date: 2005-10-15
Publish date: 2005-10-15
 
Eur J Gen Med 2005;2(4):140–143
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ABSTRACT
Aim: Jatropha gossypifolia belongs to the family “Euphorbiacea”. The coagulant activity and the mechanism of action of Jatropha gossypifolia stem latex as a haemostatic agent were investigated. Methods: The mechanism of action was investigated using doubling dilution technique by mixing neat (undiluted) and serial dilutions of the latex with 30% bovine albumin. Results: The results of whole blood clotting time using Lee and White method and bleeding time using Ivy’s method were significantly reduced (P < 0.05) when stem latex was introduced than when the tests were performed without stem latex. This means that the stem latex possesses procoagulant activity. Conclusion: The result of this test showed that precipitation of coagulant factors is the mechanism of action of its haemostatic activity.
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