ORIGINAL ARTICLE
Effect of vitamin D supplement therapy on HbA1C and IGF-1 levels in children with type 1 diabetes mellitus and vitamin D deficiency
 
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1
Department of Pediatric Endocrinology, Child growth and Development Research Center, Research Institute for primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
2
School of Medicine, Islamic Azad University of Najafabad, Isfahan, Iran
3
Department of Pediatric Islamic Azad University of Najafabad, Isfahan, Iran
4
Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Publish date: 2018-07-11
 
Electron J Gen Med 2018;15(4):em69
KEYWORDS:
ABSTRACT:
Background:
Studies indicated higher rate of vitamin D deficiency in Iranian children and also its potential role in both pathogenesis and management of Type 1 diabetes mellitus (T1DM), so we aimed to evaluate the impact of vitamin D supplement therapy on glycemic control and level of Insulin-like growth factor-I (IGF-1) in children with T1DM.

Methods:
In this cross-sectional study, a total of 30 children with T1DM and serum 25-hydroxyvitamin D levels lower than 29 ng/ml were enrolled. In addition to insulin therapy, the patients underwent treatment with 50,000 units of cholecalciferol (vitamin D3) once a week for a period of 12 weeks. Mean of serum vitamin D, IGF-1 and hemoglobin A1C (HbA1C), before and after treatment were compared.

Results:
Serum vitamin D increased significantly after 12 weeks treatment (P<0.001). Mean level of IGF-1 and HbA1c increased and decreased significantly after treatment with vitamin D supplement, respectively (P=0.01 and 0.04). There was a significant negative correlation between HbA1c and IGF-1 (r= -0.69, P<0.001) and 25(OH) D (r= -0.40, P=0.05), 12 weeks after treatment with Vitamin D3 supplement.

Conclusion:
Our results indicated that vitamin D treatment enhance level IGF-1 which was accompanied by decreased levels of HbA1c in patients with T1DM. So, developing a proper vitamin D treatment guideline specified in T1DM patients would result in better glycemic control and proper prevention of its related microvascular and macrovascular complication.

 
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