Cortical auditory plasticity in children with Cochlear implants
More details
Hide details
Hearing Research Center, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Musculoskletal Rehabilitation Research Center, School of Rehabilitation Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Department of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran
Critical Care Department,University of Manitoba,Winnipeg,Canada
Hearing Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Online publish date: 2018-08-12
Publish date: 2018-11-18
Electron J Gen Med 2018;15(6):em92
The purpose of the current study was to investigate plasticity of auditory system following cochlear implants (CI) in prelingually severe to profound hearing-impaired chil¬dren using cortical auditory evoked potentials (CAEPs) and correlate it with auditory perception performance.

A total of 28 (15 boys, 13 girls) children with profound hearing loss, who underwent CI at Ahvaz Jundishapur University of Medical Sciences, Iran, were included in this study. Their mean age at the time of implantation was 21.3 months. All children were evaluated before implantation and 3 months after implantation using the CAEPs and categorical auditory performance (CAP). For CAEP measurement, the stimuli on the HEARLab system (/m/, /g/, and /t/) were extracted from running speech and presented at 65 dB SPL.

The mean CAP and P1 amplitude values were increased from pre-CI condition to 3-month post-CI condition (Paired t-test, p<0.001). We found a positive correlation between P1 amplitude and CAP score changes from pre- to post-implantation stages (Pearson’s r=0.62, p=0.018). There was no significant difference in CAP and P1 amplitude values between boys and girls (p >0.05).

The present study indicated that early cochlear implantation, will improve cortical auditory plasticity and auditory performance ability in pre-lingual hearing-impaired children.

1. Kral A. Auditory critical periods: a review from system’s perspective. Neuroscience 2013;247:117-33. https://doi.org/10.1016/j.neur... PMid:23707979.
2. Kral A, Sharma A. Developmental neuroplasticity after cochlear implantation. Trends Neurosci. 2012;35(2):111-22. https://doi.org/10.1016/j.tins... PMid:22104561 PMCid:PMC3561718.
3. Saki N, Yadollahpour A, Moniri S, Karimi M, Bayat A, Abshirini H, et al. Investigating the impacts of cochlear implantation on the happiness and self-esteem of mothers of children with severe hearing loss. Int J Mental Health Addict 2017;15:288-94. https://doi.org/10.1007/s11469....
4. Campbell R, MacSweeney M, Woll B. Cochlear implantation (CI) for prelingual deafness: the relevance of studies of brain organization and the role of first language acquisition in considering outcome success. Front Hum Neurosci. 2014;8:834. https://doi.org/10.3389/fnhum.... PMid:25368567 PMCid:PMC4201085.
5. Burdo S, Razza S, Di Berardino F, Tognola G. Auditory cortical responses in patients with cochlear implants. Acta Otorhinolaryngol Ital 2006;26:69–77. PMid:16886849 PMCid:PMC2639983.
6. Sandmann P, Plotz K, Hauthal N, de Vos M, Schönfeld R, Debener S. Rapid bilateral improvement in auditory cortex activity in postlingually deafened adults following cochlear implantation. Clin Neurophysiol. 2015;126(3): 594-607. https://doi.org/10.1016/j.clin... PMid:25065298.
7. Petersen B, Gjedde A, Wallentin M, Vuust P. Cortical plasticity after cochlear implantation. Neural Plast 2013; 2013:318521. https://doi.org/10.1155/2013/3... PMid:24377050 PMCid:PMC3860139.
8. Kral A, Tillein J, Heid S, Klinke R, Hartmann R. Cochlear implants: cortical plasticity in congenital deprivation. Prog Brain Res 2006;157:283-313. https://doi.org/10.1016/S0079-....
9. Sharma A, Nash AA, Dorman M. Cortical development, plasticity and reorganization in children with cochlear implants. J Commun Disord 2009;42:272-79. https://doi.org/10.1016/j.jcom... PMid:19380150 PMCid:PMC2696307.
10. Lee S, Bidelman GM. Objective identification of simulated cochlear implant settings in normal-hearing listeners via auditory cortical evoked potentials. Ear Hear 2017;38(4):e215-e226. https://doi.org/10.1097/AUD.00... PMid:28125444.
11. Johnson JM. Late auditory event-related potentials in children with cochlear implants: a review. Dev Neuropsychol. 2009;34:701–20. https://doi.org/10.1080/875656... PMid:20183728.
12. Kujala T, Näätänen R. The adaptive brain: a neurophysiological perspective. Prog Neurobiol 2010;91:55–67. https://doi.org/10.1016/j.pneu... PMid:20117165.
13. Jang JH, Jang HK, Kim SE, Oh SH, Chang SO, Lee JH. Analysis of P1 latency in normal hearing and profound sensorineural hearing loss. Clin Exp Otorhinolaryngol. 2010;3(4):194-8. https://doi.org/10.3342/ceo.20... PMid:21217959 PMCid:PMC3010537.
14. Saki N, Bayat A, Hoeinabadi R, Nikakhlagh S, Karimi M, Dashti R. Universal newborn hearing screening in southwestern Iran. Int J Pediatr Otorhinolaryngol 2017;97:89-92. https://doi.org/10.1016/j.ijpo... PMid:28483258.
15. Archbold S, Lutman ME, Marshall DH. Categories of auditory performance. Ann Otol Rhinol Laryngol Suppl. 1995;166:312-14. PMid:7668685.
16. Kral A, Hartmann R, Tillein J, Heid S, Klinke R. Hearing after congenital deafness: central auditory plasticity and sensory deprivation. Cereb Cortex. 2002;12:797-807. https://doi.org/10.1093/cercor... PMid:12122028.
17. Sharma A, Nash AA, Dorman M. Clinical application of the P1 cortical auditory evoked potential biomarker in children with sensorineural hearing loss and auditory neuropathy spectrum disorder cortical development, plasticity and re-organization in children with cochlear implants. J Commun Disord. 2009;42:272–279. https://doi.org/10.1016/j.jcom... PMid:19380150 PMCid:PMC2696307.