ORIGINAL ARTICLE
Effect of the mixed herbal medicines extracts on menopausal symptoms: A randomized clinical trial study
 
More details
Hide details
1
I. M. Sechenov First Moscow State Medical University, Moscow, Russia
2
Central Clinical Hospital of Civil Aviation, Moscow, Russia
3
Sanatoriun “Laba”, Labinsk, Russia
Online publish date: 2019-05-16
Publish date: 2019-05-16
 
Electron J Gen Med 2019;16(3):em137
KEYWORDS
ABSTRACT
Background:
Menopause cause many symptoms, which may impair quality of life the women. The study aims to determine the effectiveness of mixed herbal medicinal extracts on menopausal symptoms.

Method:
A randomized, triple-blind, placebo-controlled clinical trial was conducted on 120 peri-menopausal women for 12 weeks. All participants took herbal extracts drops orally daily. They were randomly allocated into four groups: placebo (C), A (250 mg chamomile, 30 mg fennel, 15 mg saffron), B (1000 mg chamomile, 120 mg fennel, 60 mg saffron), and D (500 mg chamomile, 60 mg fennel, 30 mg saffron).They completed a demographic and MRS questionnaire at week 0, 6.12.

Result:
108 participants successfully completed the assessment. No significant differences in demographic variables were seen between the four groups. The median MRS score was significantly reduced in group B from 27.5±3 to 7.5±5. In group D, it was significantly reduced from 29±12 to 22±9.25The effect size in this study was 0.92.

Conclusion:
Study showed significant improvement in menopausal symptoms especially in group B.

 
REFERENCES (29)
1.
Stephenson KNP, Kurdowska AK. The effects of compounded bioidentical transdermal hormone therapy on hemostatic, inflammatory, immune factors; cardiovascular biomarkers; quality-of-life measures; and health outcomes in perimenopausal and postmenopausal women. International journal of pharmaceutical compounding. 2012;17(1):74-85.
 
2.
Rajaeefard A, Mohammad-Beigi A, Mohammad-Salehi N. Estimation of natural age of menopause in Iranian women: a meta-analysis study. Koomesh. 2011;13(1):1-7.
 
3.
Aidelsburger P, Schauer S, Grabein K, Wasem J. Alternative methods for the treatment of post-menopausal troubles. GMS health technology assessment. 2012;8:353-368.
 
4.
Kim M-S, Lim H-J, Yang HJ, Lee MS, Shin B-C, Ernst E. Ginseng for managing menopause symptoms: a systematic review of randomized clinical trials. J Ginseng Res. 2013;37(1):30-6. https://doi.org/10.5142/jgr.20... PMid:23717154 PMCid:PMC3659624.
 
5.
Ernst E, Pittler MH, Wider B, Boddy K. Oxford handbook of complementary medicine: OUP Oxford; 2008. https://doi.org/10.1093/med/97....
 
6.
Yakoot M, Salem A, Omar A-M. Effectiveness of a herbal formula in women with menopausal syndrome. Forschende Komplementärmedizin/Research in Complementary Medicine. 2011;18(5):264-8. https://doi.org/10.1159/000333... PMid:22105039.
 
7.
Chang A, Kwak BY, Yi K, Kim JS. The Effect of Herbal Extract (EstroG‐100) on Pre‐, Peri‐and Post‐Menopausal Women: A Randomized Double‐blind, Placebo‐controlled Study. Phytotherapy research. 2012;26(4):510-6. https://doi.org/10.1002/ptr.35... PMid:21887807.
 
8.
Sara Pourabbas M. Study of the the anxiolytic effects of fennel and possible roles of bothGABAergic system and estrogen receptors in these effects in adult female rat,. Physiology and Pharmacology. Spring [Article in Persian. 2011;15(1):134-43.
 
9.
Kim T-H KH-J, Lee S-H, Kim S-Y. Potent inhibitory effect of Foeniculum vulgare Miller extract on osteoclast differentiation and ovariectomy-induced bone loss. International journal of molecular medicine. 2012;29(6):1053.
 
10.
Malini VG, Megala N, Anusya S, Devi K, Elango V. Effect of Foeniculum vulgare Mill. Seed extract on the genital organs ofmale and female rats. indian J physiol pharmacol. 1985;29(1):21-6.
 
11.
Barene IDI, Zvirgzdina L, Iriste V. The complex technology on products of German chamomile. Medicina. 2003;39(2):127-31.
 
12.
Zeggwagh NA, Eddouks M. Vascular Effects of Aqueous Extract of Chamaemelum nobile: In Vitro Pharmacological Studies in Rats. Clinical and Experimental Hypertension. 2013;35(3):200-6. https://doi.org/10.3109/106419... PMid:22866985.
 
13.
Emamghoreishi GFY. The Effect of Subchronic Administration of the Aqueous and Hydro-alcoholic Extracts of Crocus sativus from Estahbanat, Fars Province, on Mice (in persion). Armaghane-danesh, Yasuj University of Original Article Medical Sciences Journal. 2011;2(3):115-123.
 
14.
Kashani L RF, Saroukhani S, Sohrabi H, Modabbernia A, Nasehi AA, et al. Saffron for treatment of fluoxetine‐induced sexual dysfunction in women: randomized double‐blind placebo‐controlled study. Human Psychopharmacology: Clinical and Experimental. 2013;28(1):54-60. https://doi.org/10.1002/hup.22... PMid:23280545.
 
15.
Rajput MS SS, Mathur V, Agrawal P. Herbal antidepressants international JPharmaceutical Frontier Resl. 2011;1(1):159-69.
 
16.
Kupfersztain C, Rotem C, Fagot R, Kaplan B. The immediate effect of natural plant extract, Angelica sinensis and Matricaria chamomilla (Climex) for the treatment of hot flushes during menopause. A preliminary report. Clinical and experimental obstetrics & gynecology. 2002;30(4):203-6.
 
17.
Heinemann LA, Potthoff P, Schneider HP. International versions of the menopause rating scale (MRS). Health and quality of life outcomes. 2003;1(1):28. https://doi.org/10.1186/1477-7....
 
18.
Schneider H, Heinemann L, Thiele K. The Menopause Rating Scale (MRS): cultural and linguistic translation into English. Life and Medical Science Online. 2002;3:65-73.
 
19.
Heinemann K, Ruebig A, Potthoff P, Schneider HP, Strelow F, Heinemann LA. The Menopause Rating Scale (MRS) scale: a methodological review. Health and Quality of life Outcomes. 2004;2(1):45-59. https://doi.org/10.1186/1477-7....
 
20.
Al Msae. The frequency and severity of menopausal symptoms and its relationship with personal factors the young women before and after menopause in Ahvaz. IJOGI. 2013;16:7-15.
 
21.
Jalili LHN, DPA, Najar EAMS. T. The relationship between physical activity and intensity. Menopausal symptoms in postmenopausal women in Ahvaz. IJOGI May 2014;17(98):15-23.
 
22.
S. Nazarpour MS FRT. Effects of the severity of menopausal symptoms on sexual function in postmenopausal women. JQUMS, 2015;19:54-63.
 
23.
Agha‐Hosseini MKL, Aleyaseen A, Ghoreishi A, Rahmanpour H, Zarrinara A. Crocus sativus L.(saffron) in the treatment of premenstrual syndrome: a double‐blind, randomised and placebo‐controlled trial. BJOG: An International Journal of Obstetrics & Gynaecology. 2008;115(4):515-9. https://doi.org/10.1111/j.1471... PMid:18271889.
 
24.
Amsterdam JD L SIea. A Randomized, double blind, placebo-controlled trial of oral Matricara recutita (chamomile) extract therapy for generalized anxiety disorder. J Clin Psychopharmacol. 2009;29(4):378-82. https://doi.org/10.1097/JCP.0b... PMid:19593179 PMCid:PMC3600416.
 
25.
Omidvar S ES, Baradaran M, Basirat Z. Effect of fennel on pain intensity in dysmenorrhoea: A placebo-controlled trial. AYU. 2012 Apr;33(2):311-3. https://doi.org/10.4103/0974-8... PMid:23559811 PMCid:PMC3611645.
 
26.
Nedeljkovic M, Tian L, Ji P, Déglon-Fischer A, Stute P, Ocon E, et al. Effects of acupuncture and Chinese herbal medicine (Zhi Mu 14) on hot flushes and quality of life in postmenopausal women: results of a four-arm randomized controlled pilot trial. Menopause. 2014;21(1):15-24. https://doi.org/10.1097/GME.0b... PMid:23676632.
 
27.
Akbari Torkestani N, Attarha M, Heidari T, Narenji F. The Effect of Fenugreek and Flaxseed on Menopausal Hot Flash. Complementary Medicine Journal of faculty of Nursing & Midwifery. 2011;1(1):68-74.
 
28.
Green J DA, Ingram J, Hawkey S and Greenwood R. Treatment of menopausal symptoms by qualified herbal practitioners: a prospective, randomized controlled trial. Family Practice Advance Access 14 August 2007;24:468–74. https://doi.org/10.1093/fampra... PMid:17698978.
 
29.
Plotnikoff GA, Watanabe K, Torkelson C, La Valleur J, Radosevich DM. The TU-025 Keishibukuryogan for Hot Flash Management in Postmenopausal Women: Results and Lessons for Future Research. Menopause (New York, NY). 2011;18(8):886. https://doi.org/10.1097/gme.0b... PMid:21738077 PMCid:PMC3181094.
 
eISSN:2516-3507